Human immunodeficiency virus-1 subtypes and antiretroviral drug resistance profiles among drug-naïve Brazilian blood donors
نویسندگان
چکیده
منابع مشابه
Antiretroviral drug resistance in human immunodeficiency virus type 2.
Scientists established long ago that human immunodeficiency virus type 1 (HIV-1) is the causative agent of AIDS (4, 30, 48). HIV is known to severely damage the immune system by selectively infecting T-helper (CD4 ) lymphocytes. This can lead to serious infections by agents that would normally be easily held in check by the immune system (12). In 1986, a second type of HIV, HIV-2, was identifie...
متن کاملGlobal Comparison of Drug Resistance Mutations After First-Line Antiretroviral Therapy Across Human Immunodeficiency Virus-1 Subtypes
Background. Human immunodeficiency virus (HIV)-1 drug resistance mutations (DRMs) often accompany treatment failure. Although subtype differences are widely studied, DRM comparisons between subtypes either focus on specific geographic regions or include populations with heterogeneous treatments. Methods. We characterized DRM patterns following first-line failure and their impact on future tre...
متن کاملSynonymous genetic polymorphisms within Brazilian human immunodeficiency virus Type 1 subtypes may influence mutational routes to drug resistance.
BACKGROUND Most published data on antiretroviral-drug resistance is generated from in vitro or in vivo studies of subtype B virus. However, this subtype is associated with <10% of HIV infections worldwide, and it is essential to explore subtype-specific determinants of drug resistance. One potential cause of the differences between subtypes is the synonymous codon usage at key resistance positi...
متن کاملGenotype and antiretroviral drug resistance of human immunodeficiency virus-1 in Saudi Arabia.
OBJECTIVE To analyze antiretroviral drug resistance and determine the genotype of human immunodeficiency virus (HIV)-1 in Saudi patients by sequencing an amplified region of the viral pol gene. METHODS This retrospective study analyzed data from plasma samples submitted for genotypic drug sensitivity monitoring. Samples were analyzed at the Special Infectious Agent Unit, King Fahd Medical Res...
متن کاملDemonstration of sustained drug-resistant human immunodeficiency virus type 1 lineages circulating among treatment-naïve individuals.
Transmission of human immunodeficiency virus (HIV) drug resistance is well-recognized and compromises response to first-line therapy. However, the population dynamics of transmitted resistance remains unclear, although previous models have assumed that such transmission reflects direct infection from treated individuals. We investigated whether population-based phylogenetic analyses would uncov...
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ژورنال
عنوان ژورنال: Transfusion
سال: 2006
ISSN: 0041-1132
DOI: 10.1111/j.1537-2995.2007.01069.x